PXD040143-1

PXD040143 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Effect of diabetes on the proteomic profile of serum extracellular vesicles in morbidly obese patients after bariatric surgery
Description	Obesity and diabetes are linked to cardiometabolic diseases, however study in this field faces hardships as there are substantial prognostic heterogeneity involved. To profile the molecular mechanisms that contribute to the different responses to bariatric surgery dependent on the presence of diabetes, we sought to identify extracellular vesicular proteomic signatures of obesity with or without diabetes before or after bariatric surgery. In this study, extracellular vesicle proteins in 30 morbidly obese patients with (n = 12) or without (n = 18) diabetes were sampled before or 6 months after bariatric surgery and were compared to those in 37 healthy controls, analyzed by using the SWATH-MS analysis.
HostingRepository	PRIDE
AnnounceDate	2025-10-06
AnnouncementXML	Submission_2025-10-05_19:37:51.570.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kyunggon Kim
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-16 06:48:21	ID requested
⏵ 1	2025-10-05 19:37:53	announced

Publication List

Lee H, Han JA, Ahn HS, Kwon SH, Kim K, Ryu S, Impact of diabetes on proteomic changes in circulating extracellular vesicles in individuals with obesity before and after bariatric surgery. Int J Obes (Lond), 49(9):1874-1881(2025) [pubmed]
10.1038/s41366-025-01837-y;

Lee H, Han JA, Ahn HS, Kwon SH, Kim K, Ryu S, Impact of diabetes on proteomic changes in circulating extracellular vesicles in individuals with obesity before and after bariatric surgery. Int J Obes (Lond), 49(9):1874-1881(2025) [pubmed]

10.1038/s41366-025-01837-y;

Keyword List

submitter keyword: Human, LC-MSMS, Bariatric surgery, Serum, Diabetes, Exosome, SWATH-MS

submitter keyword: Human, LC-MSMS, Bariatric surgery, Serum, Diabetes, Exosome, SWATH-MS

Contact List

Kyunggon Kim
contact affiliation	Department of Convergence Medicine, Convergence Medicine Research Center/Biomedical Research Center, Asan Medical Center, Asan Institute for Life Sciences, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea.
contact email	kkkon1@amc.seoul.kr
lab head
Kyunggon Kim
contact affiliation	Asan Medical Center
contact email	kimkyunggon@gmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD040143
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD040143

PRIDE project URI

Repository Record List

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