PXD040122-1

PXD040122 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Polyhexamethylene guanidine aerosol causes irreversible changes in blood proteins that associated with the severity of lung injury
Description	Humidifier disinfectant (HD)-associated lung injury (HDLI) not only associates with increased acute morbidity and mortality, but also affects long term lung function due to lung fibrosis. However, there have been no validated marker capable of detecting exposure to HDs or severity of HDLI. This study aims to discover the differential abundant plasma proteome between them and develop prediction score platform using plasma proteome data from HD-exposed patients in order to classify the severity of HDLI. A total of 483 samples were used in this study. The samples used were 162 children in the normal group, 76 in the 4th stage, 51 in the 3rd stage, 54 in the 2nd stage, 42 in the 1st stage and 50 female adults in the normal group, 20 in the 4th stage, 7 in the 3rd stage, 6 in the 2nd stage, and 14 in 1st stage. The lower the grade, the greater the severity of HDLI.
HostingRepository	PRIDE
AnnounceDate	2024-08-14
AnnouncementXML	Submission_2024-08-14_05:48:55.052.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hee-Sung Ahn
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-15 05:38:06	ID requested
⏵ 1	2024-08-14 05:48:55	announced

Publication List

10.1016/j.jhazmat.2024.135359;
Ahn HS, Lee SY, Kang MJ, Hong SB, Song JW, Do KH, Yeom J, Yu J, Oh Y, Hong JY, Chung EH, Kim K, Hong SJ, Polyhexamethylene guanidine aerosol causes irreversible changes in blood proteins that associated with the severity of lung injury. J Hazard Mater, 478():135359(2024) [pubmed]

10.1016/j.jhazmat.2024.135359;

Ahn HS, Lee SY, Kang MJ, Hong SB, Song JW, Do KH, Yeom J, Yu J, Oh Y, Hong JY, Chung EH, Kim K, Hong SJ, Polyhexamethylene guanidine aerosol causes irreversible changes in blood proteins that associated with the severity of lung injury. J Hazard Mater, 478():135359(2024) [pubmed]

Keyword List

submitter keyword: LC-MSMS, lung injury, chemically-induced disorders;, SWATH-MS, Disinfectants,Human Plasma

submitter keyword: LC-MSMS, lung injury, chemically-induced disorders;, SWATH-MS, Disinfectants,Human Plasma

Contact List

Kyunggon Kim
contact affiliation	Department of Convergence Medicine, Convergence Medicine Research Center/Biomedical Research Center, Asan Medical Center, Asan Institute for Life Sciences, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea.
contact email	kkkon1@amc.seoul.kr
lab head
Hee-Sung Ahn
contact affiliation	Asan Medical Center
contact email	zaulim3@gmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD040122
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD040122

PRIDE project URI

Repository Record List

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