PXD039853-1

PXD039853 is an original dataset announced via ProteomeXchange.

Title	MS-based proteomic characterization of SIN3-containing complexes in C. elegans
Description	The SIN3 transcriptional coregulator influences gene expression through multiple interactions that include histone deacetylases (HDACs). Haploinsufficiency and mutations in SIN3 are the underlying cause of Witteveen-Kolk syndrome and related intellectual disability (ID)/autism syndromes, emphasizing its key role in development. However, little is known about the diversity of its interactions and functions in developmental processes. To gain insight in the repertoire of proteins that interact with SIN-3, we performed IP-MS on mCherry::SIN-3 expressing embryos. Furthermore, we analyzed the partnership of ARID-1::GFP, ARID-1 being an already described subunit of the SIN-3L complex.
HostingRepository	PRIDE
AnnounceDate	2023-10-02
AnnouncementXML	Submission_2023-10-01_23:33:01.573.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD039853
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	YohannCouté
SpeciesList	scientific name: Caenorhabditis elegans; NCBI TaxID: 6239;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-03 15:30:27	ID requested
⏵ 1	2023-10-01 23:33:01	announced

10.6019/PXD039853;

submitter keyword: Caenorhabditis elegans, co-immunoprecipitation, SIN3 transcriptional coregulator , nanoLC-MS/MS

YohannCouté
contact affiliation	EDyP
contact email	yohann.coute@cea.fr
lab head
YohannCouté
contact affiliation	EDyP
contact email	yohann.coute@cea.fr
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD039853
     1. Label: PRIDE project
     2. Name: MS-based proteomic characterization of SIN3-containing complexes in C. elegans