PXD039847-2

PXD039847 is an original dataset announced via ProteomeXchange.

Title	Bottom-up Proteomics of Saliva in Autoimmune Hepatitis and Primary Biliary Cholangitis
Description	Autoimmune Hepatitis (AIH) and Primary Biliary Cholangitis (PBC) are autoimmune diseases that target the liver in which the immune system produces an inappropriate response to self-antigens resulting in inflammation, damage, and dysfunction of hepatic tissues. Despite progress in the understanding of the etiopathogenesis and in the diagnostic and therapeutic approach of these diseases, critical issues remain concerning the early diagnosis of affected individuals. The present study aims to detect and characterize by a gel-based bottom-up proteomic approach the acid-insoluble fraction of salivary proteome from patients affected by AIH and PBC with respect to healthy controls (HCs). The study was performed on the salivary acid-insoluble proteins after in-gel digestion starting from: i) the entire SDS-PAGE lane; ii) a portion of the SDS-PAGE at lowest molecular weight (MW
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:09:35.126.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Giulia Guadalupi
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetic acid derivatized residue
Instrument	Q Exactive; LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-03 15:25:26	ID requested
1	2023-10-24 12:21:59	announced
⏵ 2	2023-11-14 09:09:36	announced	2023-11-14: Updated project metadata.
3	2024-10-22 06:09:45	announced	2024-10-22: Updated project metadata.

Guadalupi G, Contini C, Iavarone F, Castagnola M, Messana I, Faa G, Onali S, Chessa L, Vitorino R, Amado F, Diaz G, Manconi B, Cabras T, Olianas A, Combined Salivary Proteome Profiling and Machine Learning Analysis Provides Insight into Molecular Signature for Autoimmune Liver Diseases Classification. Int J Mol Sci, 24(15):(2023) [pubmed]

submitter keyword: Autoimmune Hepatitis, saliva, Primary Biliary Cholangitis, Bottom-up proteomics,Autoimmune Liver Diseases, LC-MS/MS

Barbara Manconi
contact affiliation	Life and Environmental Sciences Department (Biomedical Section) - University of Cagliari
contact email	bmanconi@unica.it
lab head
Giulia Guadalupi
contact affiliation	Life and Environmental Sciences Department (Biomedical Section) - University of Cagliari
contact email	giulia.guadalupi@unica.it
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD039847

PRIDE project URI

• PRIDE
  1. PXD039847
     1. Label: PRIDE project
     2. Name: Bottom-up Proteomics of Saliva in Autoimmune Hepatitis and Primary Biliary Cholangitis