PXD039838-1

PXD039838 is an original dataset announced via ProteomeXchange.

Title	Site-specific glycan analysis of ErbB2 in breast cancer cell BT474
Description	This study provides site-specific profiles of asparagine-linked and serine/threonine-linked glycosylations on ErbB2, a therapeutic target RTK for ErbB2-positive cancer, through structural analysis of recombinant ErbB2 extracellular region and endogenous ErbB2 from ErbB2-positive breast cancer cells. Furthermore, comparison of the N-glycosylated structures of the extracellular regions of ErbB2 and its homologue, the epidermal growth factor receptor (EGFR), showed differences in the distribution and density of N-glycans on both molecules, providing new insights into the different activation mechanisms of ErbB2 and EGFR from a glycan perspective.
HostingRepository	PRIDE
AnnounceDate	2024-05-24
AnnouncementXML	Submission_2024-05-24_01:02:11.993.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD039838
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Naoki Fujitani
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-02-03 06:44:19	ID requested
⏵ 1	2024-05-24 01:02:12	announced

10.1093/glycob/cwad100;

10.6019/PXD039838;

Fujitani N, Uehara Y, Ariki S, Hashimoto U, Mukai J, Hasegawa Y, Takahashi M, Site-specific glycosylation analysis of epidermal growth factor receptor 2 (ErbB2): exploring structure and function toward therapeutic targeting. Glycobiology, 34(3):(2024) [pubmed]

submitter keyword: breast cancer, ErbB2,HER2

Motoko Takahashi
contact affiliation	Department of Biochemistry, Sapporo Medical University School of Medicine
contact email	takam@sapmed.ac.jp
lab head
Naoki Fujitani
contact affiliation	Sapporo Medical University
contact email	fujitani@sapmed.ac.jp
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD039838

PRIDE project URI

• PRIDE
  1. PXD039838
     1. Label: PRIDE project
     2. Name: Site-specific glycan analysis of ErbB2 in breast cancer cell BT474