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PXD039591-1

PXD039591 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleTGF-β signaling activation modulates the biology of tumor-derived extracellular cellular vesicles
DescriptionTumor-derived extracellular vesicles (EVs) have been associated with cancer progression and metastasis due to the transfer of bioactive molecules in between the tumor microenvironment. Although Transforming Growth Factor-β (TGF-β) signaling associated molecules have been implicated as cargo of EVs, the role of TGF-β pathway on EV’s biology to promote tumorigenesis is poorly understood. Hence, we aimed to describe the impact of TGF-β signaling on biogenesis and functional transfer of cargo from tumor-derived EVs induced by TGF-β (EV+TGF-β1). To this end, EV-fractions enriched in CD81 or Cholerae toxin B chain (CTB) were isolated from the vesicular secretome fraction (VSF) of human breast cancer and lung adenocarcinoma cells and further characterized.
HostingRepositoryPRIDE
AnnounceDate2025-05-06
AnnouncementXMLSubmission_2025-05-06_09:29:02.989.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJosé Eduardo Araújo
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-01-20 06:12:18ID requested
12025-05-06 09:29:03announced
Publication List
10.1186/s13046-025-03291-0;
Rodrigues-Junior DM, Tsirigoti C, Psatha K, Kletsas D, Aivaliotis M, Heldin CH, Moustakas A, induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles. J Exp Clin Cancer Res, 44(1):42(2025) [pubmed]
Keyword List
submitter keyword: Extracellular vesicles (EV), Transforming Growth Factor β (TGF- β), Cancer, Drug resistance, Metastasis
Contact List
Janne Lehtiö
contact affiliationOncology Pathology, Karolinska Institutet, and Scilifelab, Stockholm, Sweden
contact emailjanne.lehtio@ki.se
lab head
José Eduardo Araújo
contact affiliationClinical Proteomics Mass Spectrometry, SciLifeLab, Karolinska Institutet
contact emailjose-eduardo.araujo@scilifelab.se
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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