PXD039501-1

PXD039501 is an original dataset announced via ProteomeXchange.

Title	The small molecule lipoamide modulates stress granule condensation with beneficial outcomes for familial amyotrophic lateral sclerosis models
Description	We have evaluate the in-situ targets of lipoamide - a compund that causes alteration of the fluidity of in-vito FUS condensate and dissolves stress granules in cells - in Hela cells stressed with 1 mM arsenate. We have used quantitative proteomics based thermal proteome profiling to characterise the system-wide targets of this compound. Conventional TPP protocol described in Becher et al., 2016 was used.
HostingRepository	PRIDE
AnnounceDate	2025-05-09
AnnouncementXML	Submission_2025-05-09_07:21:37.283.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sindhuja Sridharan
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-01-16 15:44:25	ID requested
⏵ 1	2025-05-09 07:21:37	announced

Dataset with its publication pending

submitter keyword: target engagement, thermal proteome profiling, ALS, biomolecular condensates,lipoamide

Mikhail M. Savitski
contact affiliation	European Molecular Biology Laboratory
contact email	mikhail.savitski@embl.de
lab head
Sindhuja Sridharan
contact affiliation	European Molecular Biology Laboratory
contact email	sindhuja.sridharan@embl.de
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD039501
     1. Label: PRIDE project
     2. Name: The small molecule lipoamide modulates stress granule condensation with beneficial outcomes for familial amyotrophic lateral sclerosis models