PXD039473-1

PXD039473 is an original dataset announced via ProteomeXchange.

Title	Identification of host targets of Vpu based on APEX2 proximity labeling
Description	The HIV-1 accessory proteins Vpu antagonize a variety of host restriction factors, thus leading to the escape of host immune surveillance and the promotion of virus release. However, the interaction between Vpu and the host proteins has not been fully clarified. Here, we utilized APEX2-based proximity labeling and transmission electron microscope, as well as Immunoprecipitation-Mass spectrometry to characterize the interaction between HIV-1 Vpu and host proteins. We identified 21 cellular targets of Vpu and found the targets were enriched in RNA transport and spliceosome pathway.
HostingRepository	PRIDE
AnnounceDate	2025-07-21
AnnouncementXML	Submission_2025-07-21_02:15:22.904.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Boye Li
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2023-01-16 08:17:50	ID requested
⏵ 1	2025-07-21 02:15:23	announced

10.1128/MSYSTEMS.00403-25;

submitter keyword: protein-protein interaction, engineered ascorbate peroxidase labeling,Viral protein U

Boye Li
contact affiliation	Civil Aviation Medicine Center, Civil Aviation Administration of China
contact email	liboye1994@163.com
lab head
Boye Li
contact affiliation	Civil Aviation Medicine Center, Civil Aviation Administration of China
contact email	liboye1994@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD039473

PRIDE project URI

• PRIDE
  1. PXD039473
     1. Label: PRIDE project
     2. Name: Identification of host targets of Vpu based on APEX2 proximity labeling