PXD039471 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Changes in the proteome of human induced pluripotent stem cells derived endothelial cells with CRISPR/Cas9 induced monoallelic and biallelic mutation of the HNF1A gene |
| Description | Maturity onset diabetes of the young (MODY) is caused by a mutation in a single gene and leads to diabetes under the age of 25. The mutations in HNF1A gene (leading to HNF1A-MODY) cause about 70% of all MODY cases. It was shown that patients with HNF1A-MODY often develop diabetic microvascular complications, related to endothelial dysfunction, however, it is not clear whether these complications are the result of hyperglycemia or due to the genetic mutation in HNF1A gene. For analysis, monoallelic (MAC) and biallelic (BAC) mutants in the HNF1A gene were used for comparative proteomics to the isogenic control (hiPSCs-EC). |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-03-01 |
| AnnouncementXML | Submission_2026-03-01_10:38:30.307.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Neli Kachamakova-Trojanowska |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2023-01-16 08:16:44 | ID requested | |
| ⏵ 1 | 2026-03-01 10:38:30 | announced | |
Publication List
Keyword List
| submitter keyword: Maturity onset diabetes of the young, endothelial cells,HNF1A-MODY, iPSCs-EC |
Contact List
| Neli Kachamakova-Trojanowska |
|---|
| contact affiliation | Molecular Mechanisms of Disease Research Group, Malopolska Centre of Biotechnology, Jagiellonian University, 30-387 Krakow, Poland |
| contact email | neli.kachamakova-trojanowska@uj.edu.pl |
| lab head | |
| Neli Kachamakova-Trojanowska |
|---|
| contact affiliation | Malopolska Centre of Biotechnology, Jagiellonian University |
| contact email | neli.kachamakova-trojanowska@uj.edu.pl |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD039471 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD039471
- Label: PRIDE project
- Name: Changes in the proteome of human induced pluripotent stem cells derived endothelial cells with CRISPR/Cas9 induced monoallelic and biallelic mutation of the HNF1A gene
