PXD039436-3

PXD039436 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Two elongasomes generate rod shape in a unicellular microorganism
Description	Cell geometry is genetically inherited by all forms of life. In bacteria, shape is determined by the peptidoglycan and is nearly invariant during the metabolically active vegetative state. Essential morphogenetic complexes, the elongasome and divisome, expand the peptidoglycan along the major and minor axes, respectively, to generate a particular shape. Here, we provide evidence for the presence in Salmonella of two alternative elongasomes that generate a similar (rod) shape. One elongasome is directed by penicillin-binding protein 2 (PBP2) while the other is controlled by PBP2SAL, a pathogen-specific enzyme. In acidic niches, PBP2SAL replaces and renders dispensable PBP2. Our data also demonstrate distinct rates for the two identified elongasomes, with that directed by PBP2SAL exhibiting lower speed
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:05:30.691.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD039436
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Alberto Paradela
SpeciesList	scientific name: Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344; NCBI TaxID: 216597;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 240

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-01-13 14:28:36	ID requested
1	2023-08-15 10:51:00	announced
2	2023-09-28 04:08:29	announced	2023-09-28: Updated project metadata.
⏵ 3	2023-11-14 09:05:35	announced	2023-11-14: Updated project metadata.
4	2024-10-22 06:00:29	announced	2024-10-22: Updated project metadata.

Publication List

Castanheira S, Garc, í, a-Del Portillo F, Evidence of two differentially regulated elongasomes in Salmonella. Commun Biol, 6(1):923(2023) [pubmed]
10.6019/PXD039436;

Castanheira S, Garc, í, a-Del Portillo F, Evidence of two differentially regulated elongasomes in Salmonella. Commun Biol, 6(1):923(2023) [pubmed]

10.6019/PXD039436;

Keyword List

submitter keyword: Salmonella
peptidoglycan
elongasome
PBP2
PBP2SAL

submitter keyword: Salmonella

peptidoglycan

elongasome

PBP2

PBP2SAL

Contact List

Francisco Garcia del Portillo
contact affiliation	DEPARTMENT OF MICROBIAL BIOTECHNOLOGY LABORATORY OF INTRACELLULAR BACTERIAL PATHOGENS NATIONAL CENTER FOR BIOTECHNOLOGY CSIC SPAIN
contact email	fgportillo@cnb.csic.es
lab head
Alberto Paradela
contact affiliation	CNB-CSIC
contact email	alberto.paradela@cnb.csic.es
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/08/PXD039436
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/08/PXD039436

PRIDE project URI

Repository Record List

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