PXD039337-2

PXD039337 is an original dataset announced via ProteomeXchange.

Title	HIC1 interacts with FOXP3 multi protein complex: a novel mechanism to regulate human regulatory T cell differentiation and function
Description	Recent data have shown that Hypermethylated in cancer 1 (HIC1) is an important contributor to iTreg cell development and function. Using affinity-purification and tandem mass spectrometry we systematically characterized the HIC-1 interactome in human iTreg cells. On the basis of these data, we have shown that HIC1 is a part of FOXP3-RUNX1-CBFβ protein complex that regulates Treg signature genes and is indispensable for the suppressive function of FOXP3+ regulatory T cells. SRM was used to validate HIC1 interactors
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:05:56.874.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Robert Moulder
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-01-09 07:36:38	ID requested
1	2023-10-16 01:28:35	announced
⏵ 2	2023-11-14 09:05:57	announced	2023-11-14: Updated project metadata.
3	2024-10-22 06:06:00	announced	2024-10-22: Updated project metadata.

Andrabi SBA, Batkulwar K, Bhosale SD, Moulder R, Khan MH, Buchacher T, Khan MM, Arnkil I, Rasool O, Marson A, Kalim UU, Lahesmaa R, HIC1 interacts with FOXP3 multi protein complex: Novel pleiotropic mechanisms to regulate human regulatory T cell differentiation and function. Immunol Lett, 263():123-132(2023) [pubmed]

submitter keyword: HIC1

Interactome

Immunoprecipitation

Proteomics

FOXP3

Protein complex

RUNX1

Regulatory T cells

T cell differentiation

TGF-β

Treg

iTreg.

Professor Riitta Lahesmaa
contact affiliation	Turku Bioscience, University of Turku and Åbo Akademi University
contact email	rilahes@utu.fi
lab head
Robert Moulder
contact affiliation	Turku Biosciences
contact email	rmoulder@btk.fi
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD039337

PRIDE project URI

• PRIDE
  1. PXD039337
     1. Label: PRIDE project
     2. Name: HIC1 interacts with FOXP3 multi protein complex: a novel mechanism to regulate human regulatory T cell differentiation and function