PXD039214-2

PXD039214 is an original dataset announced via ProteomeXchange.

Title	Patient-derived podocyte spheroids reveals new insights into the etiopathogenesis of Alport Syndrome
Description	Alport syndrome (AS) is a rare disease characterized by defective glomerular basement membranes, caused by mutations in COL4A3, COL4A4 and COL4A5, which synthesize collagen type IV. Patients present with progressive proteinuria, hematuria and podocyte loss. There is currently no cure for AS, and this is mainly due to its complex and variable pathogenesis, as well as the lack of models that can faithfully mimic the human phenotype.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:00:21.434.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sadr Shaheed
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2023-01-03 01:00:49	ID requested
1	2023-02-21 05:11:17	announced
⏵ 2	2023-11-14 09:00:21	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: human disease model, proteomics,Alport syndrome, hiPSCs, stem cells, kidney, spheroids

Dr Sadr ul Shaheed
contact affiliation	Nuffield department of Surgical Sciences, University of Oxford UK
contact email	sadr.shaheed@nds.ox.ac.uk
lab head
Sadr Shaheed
contact affiliation	Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom
contact email	sadr.shaheed@nds.ox.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/02/PXD039214

PRIDE project URI

• PRIDE
  1. PXD039214
     1. Label: PRIDE project
     2. Name: Patient-derived podocyte spheroids reveals new insights into the etiopathogenesis of Alport Syndrome