PXD039190-1

PXD039190 is an original dataset announced via ProteomeXchange.

Title	spint1 specific knokout in mouse pancreas islet SILAC
Description	SPINT1 is a membrane-anchored serine protease inhibitor that modulates pericellular proteolysis. The pancreas-specific disruption of Spint1 in mice significantly decreased islet size and mass, leading to glucose intolerance, which was causally related to the down-regulation of MafA and insulin. Mechanistically, the silencing of Hepsin (encoding a SPINT1 target protease) counteracted the repressive effect of Spint1 knockdown on MafA and Ins1 expression in β cells. Together, the results suggest that SPINT1 plays a novel role in β cells to maintain glucose homeostasis and insulin production.
HostingRepository	PRIDE
AnnounceDate	2024-11-01
AnnouncementXML	Submission_2024-11-01_09:14:33.712.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lin hsin-hsien
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2023-01-02 19:15:55	ID requested
⏵ 1	2024-11-01 09:14:34	announced

Dataset with its publication pending

submitter keyword: spint1, SILAC, islet, mouse

Ming-Shyue Lee
contact affiliation	Department of Biochemistry and Molecular Biology College of Medicine, National Taiwan University, Taipei, Taiwan
contact email	mslee2006@ntu.edu.tw
lab head
Lin hsin-hsien
contact affiliation	National Taiwan University, College of Medicine, Biochemistry and Molecular Biology
contact email	dtsh5300175@yahoo.com.tw
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/11/PXD039190

PRIDE project URI

• PRIDE
  1. PXD039190
     1. Label: PRIDE project
     2. Name: spint1 specific knokout in mouse pancreas islet SILAC