PXD039103-2

PXD039103 is an original dataset announced via ProteomeXchange.

Title	The S/T/Y-linked residue pairs identified by current software are unreliable
Description	Here, by setting amino acids with chemically inert side chains such as glycine (G), valine (V), and leucine (L) as cross-linkable sites, which serves as a negative control, we show that the identifications of S/T/Y-linked peptides are as reliable as those of G/V/L-linked peptides. This is true across different NHS ester cross-linkers including DSS, DSSO, and DSBU, and across different search engines including MeroX, xiSearch, and pLink.
HostingRepository	iProX
AnnounceDate	2022-12-26
AnnouncementXML	Submission_2022-12-26_22:13:48.553.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yong Cao
SpeciesList	scientific name: Bos taurus; NCBI TaxID: 9913;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion; Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-12-26 19:10:20	ID requested
1	2022-12-26 19:10:38	announced
⏵ 2	2022-12-26 22:13:48	announced	2022-12-27: Update information

Dataset with its publication pending

submitter keyword: CXMS, cross-linking MS, S/T/Y-cross-link

Mengqiu Dong
contact affiliation	National Institute of Biological Sciences, Beijing
contact email	dongmengqiu@nibs.ac.cn
lab head
Yong Cao
contact affiliation	National Institute of Biological Sciences, Beijing
contact email	caoyong@nibs.ac.cn
dataset submitter

iProX dataset URI