PXD039095-1

PXD039095 is an original dataset announced via ProteomeXchange.

Title	Proteomics Characterization of human COVID-19 tissues
Description	The COVID-19 pandemic has emerged as a global health emergency due to its association with severe pneumonia and relative high mortality. However, the molecular characteristics and pathological features underlying COVID-19 pneumonia remain largely unknown. To characterize molecular mechanisms underlying COVID-19 pathogenesis in the lung tissue using a proteomic approach, fresh lung tissues were obtained from newly deceased patients with COVID-19 pneumonia. After virus inactivation, a quantitative proteomic approach combined with bioinformatics analysis was used to detect proteomic changes in the SARS-CoV-2 infected lung tissues. We identified significant differentially expressed proteins involved in a variety of fundamental biological processes including cellular metabolism, blood coagulation, immune response, angiogenesis, and cell microenvironment regulation. Several inflammatory factors were up-regulated, which was possibly caused by the activation of NF-κB signaling. Extensive dysregulation of the lung proteome in response to SARS-CoV-2 infection was discovered. Our results systematically outlined the molecular pathological features in terms of the lung response to SARS-CoV-2 infection, and provided the scientific basis for the therapeutic target that is urgently needed to control the COVID-19 pandemic.
HostingRepository	iProX
AnnounceDate	2022-12-23
AnnouncementXML	Submission_2022-12-23_20:05:55.507.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jie Ma
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF; LTQ FT

Revision	Datetime	Status	ChangeLog Entry
0	2022-12-23 20:05:45	ID requested
⏵ 1	2022-12-23 20:05:55	announced

Dataset with its publication pending

submitter keyword: COVID-19, human tissue, proteomics

Yunping Zhu
contact affiliation	National Center for Protein Sciences (Beijing)
contact email	zhuyunping@ncpsb.org.cn
lab head
Jie Ma
contact affiliation	National Center for Protein Sciences (Beijing)
contact email	majie@ncpsb.org.cn
dataset submitter

iProX dataset URI