PXD039012-1

PXD039012 is an original dataset announced via ProteomeXchange.

Title	Kinase Impaired BTK Mutations Are Susceptible to Clinical Stage BTK and IKZF1/3 Degrader NX-2127
Description	Here we identify that drug-resistant BTK mutations occur in distinct enzymatic classes, some of which render BTK enzymatically impaired while conferring novel protein-protein interactions to sustain B-cell receptor (BCR) signaling.
HostingRepository	PRIDE
AnnounceDate	2023-12-09
AnnouncementXML	Submission_2023-12-08_16:15:27.646.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Skye Montoya
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-12-20 23:34:36	ID requested
⏵ 1	2023-12-08 16:15:28	announced
2	2024-10-22 06:16:58	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: Kinase dead,BTK, phosphoproteomics

Justin Taylor
contact affiliation	Sylvester Comprehensive Cancer Center at the University of Miami
contact email	jxt1091@miami.edu
lab head
Skye Montoya
contact affiliation	University of Miami - Sylvester Comprehensive Cancer Center
contact email	osg16@miami.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/12/PXD039012

PRIDE project URI

• PRIDE
  1. PXD039012
     1. Label: PRIDE project
     2. Name: Kinase Impaired BTK Mutations Are Susceptible to Clinical Stage BTK and IKZF1/3 Degrader NX-2127