PXD038966-1

PXD038966 is an original dataset announced via ProteomeXchange.

Title	Proteomics analysis on SETD2 loss induced ccRCC formation
Description	Patients with polycystic kidney disease (PKD) encounter a high risk of clear cell renal cell carcinoma (ccRCC), a malignant tumor with dysregulated lipid metabolism. SET domain–containing 2 (SETD2) has been identified as an important tumor suppressor gene in ccRCC. However, the role of SETD2 in tumorigenesis during the transition from PKD to ccRCC remains largely unexplored. Herein, we performed metabolomics, lipidomics, transcriptomics and proteomics with SETD2 loss induced PKD-ccRCC transition mouse model. To characterize biological responses triggered by SETD2 deletion during PKD-ccRCC transition at the protein level, we conducted global proteomics studies.
HostingRepository	PRIDE
AnnounceDate	2023-10-31
AnnouncementXML	Submission_2023-10-31_05:47:14.709.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Raohanyu
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2022-12-20 06:55:30	ID requested
⏵ 1	2023-10-31 05:47:15	announced

Dataset with its publication pending

ProteomeXchange project tag: Cancer (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project

submitter keyword: Polycystic kidney disease (PKD), SET domain–containing 2 (SETD2), Clear cell renal cell carcinoma (ccRCC)

XiantingDing
contact affiliation	Shanghai Jiao Tong University
contact email	dingxianting@sjtu.edu.cn
lab head
Raohanyu
contact affiliation	Shanghai Jiao Tong University
contact email	raohanyu@sjtu.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD038966

PRIDE project URI

• PRIDE
  1. PXD038966
     1. Label: PRIDE project
     2. Name: Proteomics analysis on SETD2 loss induced ccRCC formation