PXD038870 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Tryptophan zipper hydrogels: bioactive self-healing antimicrobial matrices |
| Description | Natural materials can reversibly self-assemble into hierarchical networks with diverse structural and functional properties. Recreating these dynamic architectures using peptide-based synthetic materials has been an elusive goal, hindered by challenges in relating sequence to structure to function. Here we report on the de novo discovery of short peptides based on the “tryptophan zipper” (Trpzip) motif that self-assemble into hierarchically structured hydrogels. Trpzip hydrogels have a tunable modulus and show self-healing, stress relaxation, antimicrobial properties, and biocompatibility. The low yield point allows syringe extrusion with cytoprotection, and cell harvest with a flick of the wrist. Integrating a pendant cell adhesion motif promotes human intestinal organoid growth and differentiation, with polarity control and improved shape fidelity. Considering these unique characteristics, we anticipate Trpzip hydrogels will prove a versatile reagent for biotechnology and medicine. |
| HostingRepository | PRIDE |
| AnnounceDate | 2023-11-05 |
| AnnouncementXML | Submission_2023-11-05_10:30:31.663.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | AbhishekVijayan |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2022-12-16 00:06:30 | ID requested | |
| 1 | 2023-10-24 22:25:08 | announced | |
| ⏵ 2 | 2023-11-05 10:30:32 | announced | 2023-11-05: Updated project metadata. |
| 3 | 2023-11-14 09:11:36 | announced | 2023-11-14: Updated project metadata. |
| 4 | 2023-11-14 09:13:44 | announced | 2023-11-14: Updated project metadata. |
| 5 | 2024-10-22 06:13:16 | announced | 2024-10-22: Updated project metadata. |
Publication List
| Nguyen AK, Molley TG, Kardia E, Ganda S, Chakraborty S, Wong SL, Ruan J, Yee BE, Mata J, Vijayan A, Kumar N, Tilley RD, Waters SA, Kilian KA, Hierarchical assembly of tryptophan zipper peptides into stress-relaxing bioactive hydrogels. Nat Commun, 14(1):6604(2023) [pubmed] |
Keyword List
| submitter keyword: Organoids, Matrigel,Hydrogel |
Contact List
| ShafaghWaters |
|---|
| contact affiliation | School of Biomedical Sciences, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, 2052, Australia |
| contact email | shafagh.waters@unsw.edu.au |
| lab head | |
| AbhishekVijayan |
|---|
| contact affiliation | UNSW Sydney |
| contact email | abhishek.kcvijayan@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD038870 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD038870
- Label: PRIDE project
- Name: Tryptophan zipper hydrogels: bioactive self-healing antimicrobial matrices
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