PXD038850 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | PRODUCT CHARACTERIZATION AND PRECLINICAL SAFETY OF UMBILICAL CORD MESENCHYMAL STROMAL CELL-DERIVED SMALL EXTRACELLULAR VESICLES |
Description | Mesenchymal stromal cells (MSCs) are multipotent progenitors that can be isolated from different sources, such as the bone marrow, adipose tissue and umbilical cord. The therapeutic potential of MSCs is related to a plethora of immunomodulatory, anti-inflammatory and pro-repair actions, which are at least partially dependent on their secretome. Among the components of MSCs' secretome, EVs have received considerable attention because MSC-EVs exert similar therapeutic properties as their parent cells. Among the different MSC sources for EV production, human umbilical cord MSCs (hUCMSCs) show advantages such as tissue availability, high proliferative profile of the cells and potential beneficial therapeutic effects in a variety of different diseases, such as stroke This study aimed to provide novel insights for future hUCMSC-EVs research and treatment selection. We investigated the influence of the culture and harvesting conditions on the EV proteomic profile, productivity, surface markers expression and evaluated their in vivo biodistribution and toxicity. |
HostingRepository | PRIDE |
AnnounceDate | 2024-05-04 |
AnnouncementXML | Submission_2024-05-04_08:10:43.475.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Gisele Rocha |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | LTQ Orbitrap XL ETD |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-12-14 22:07:09 | ID requested | |
⏵ 1 | 2024-05-04 08:10:44 | announced | |
Publication List
Keyword List
submitter keyword: mesenchymal stromal cells |
extracellular vesicles |
proteomics |
preclinical |
biodistribution |
Contact List
Bruno Solano de Freitas Souza |
contact affiliation | Gonçalo Moniz Institute, FIOCRUZ, Salvador, Brazil D'Or Institute for Research and Education (IDOR), Salvador, Brazil Center for Biotechnology and Cell Therapy, São Rafael Hospital, Salvador, Brazil |
contact email | bruno.solano@fiocruz.br |
lab head | |
Gisele Rocha |
contact affiliation | D'Or Institute for Research and Education (IDOR) Gonçalo Moniz Institute, FIOCRUZ |
contact email | givieiraroch@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD038850 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD038850
- Label: PRIDE project
- Name: PRODUCT CHARACTERIZATION AND PRECLINICAL SAFETY OF UMBILICAL CORD MESENCHYMAL STROMAL CELL-DERIVED SMALL EXTRACELLULAR VESICLES