PXD038691 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Immune surveillance of acute myeloid leukemia is mediated by HLA-presented antigens on leukemia progenitor cells |
Description | Persistent therapy-resistant leukemic progenitor cells (LPC) are a main cause of disease relapse and recurrence in acute myeloid leukemia (AML). Specific LPC-targeting therapies may thus improve treatment outcome of AML patients. We demonstrate that LPCs present human leukocyte antigen (HLA)-restricted cancer antigens that induce T cell responses allowing for immune surveillance of AML. Using a mass spectrometry-based immunopeptidomics approach we characterized the antigenic landscape of patient LPCs and identify AML/LPC-associated HLA-presented antigens as well as mutation-derived and cryptic neoepitopes as prime targets for development of T cell-based immunotherapeutic approaches. We observed frequent spontaneous memory T cells targeting these AML/LPC-associated antigens in AML patients and showed that antigen-specific T cell recognition and HLA class II immunopeptidome diversity impacts clinical outcome. Our results pave the way for implementation of AML/LPC-associated antigens for T cell-based immunotherapeutic approaches to specifically target and eliminate residual LPCs in AML patients. |
HostingRepository | PRIDE |
AnnounceDate | 2023-08-23 |
AnnouncementXML | Submission_2023-08-23_11:09:30.207.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | AnnikaNelde |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-12-08 16:22:15 | ID requested | |
⏵ 1 | 2023-08-23 11:09:30 | announced | |
2 | 2024-10-22 06:01:32 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: mass spectrometry, acute myeloid leukemia, immunotherapy, immunopeptidomics, leukemic progenitor cells,HLA peptides |
Contact List
Juliane S.Walz |
contact affiliation | Department of Peptide-based Immunotherapy, University and University Hospital Tübingen, Tübingen, Germany |
contact email | juliane.walz@med.uni-tuebingen.de |
lab head | |
AnnikaNelde |
contact affiliation | Department of Peptide-based Immunotherapy, University and University Hospital Tübingen, Tübingen, Germany |
contact email | annika.nelde@uni-tuebingen.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD038691
- Label: PRIDE project
- Name: Immune surveillance of acute myeloid leukemia is mediated by HLA-presented antigens on leukemia progenitor cells