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PXD038691-1

PXD038691 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleImmune surveillance of acute myeloid leukemia is mediated by HLA-presented antigens on leukemia progenitor cells
DescriptionPersistent therapy-resistant leukemic progenitor cells (LPC) are a main cause of disease relapse and recurrence in acute myeloid leukemia (AML). Specific LPC-targeting therapies may thus improve treatment outcome of AML patients. We demonstrate that LPCs present human leukocyte antigen (HLA)-restricted cancer antigens that induce T cell responses allowing for immune surveillance of AML. Using a mass spectrometry-based immunopeptidomics approach we characterized the antigenic landscape of patient LPCs and identify AML/LPC-associated HLA-presented antigens as well as mutation-derived and cryptic neoepitopes as prime targets for development of T cell-based immunotherapeutic approaches. We observed frequent spontaneous memory T cells targeting these AML/LPC-associated antigens in AML patients and showed that antigen-specific T cell recognition and HLA class II immunopeptidome diversity impacts clinical outcome. Our results pave the way for implementation of AML/LPC-associated antigens for T cell-based immunotherapeutic approaches to specifically target and eliminate residual LPCs in AML patients.
HostingRepositoryPRIDE
AnnounceDate2023-08-23
AnnouncementXMLSubmission_2023-08-23_11:09:30.207.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAnnikaNelde
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-12-08 16:22:15ID requested
12023-08-23 11:09:30announced
22024-10-22 06:01:32announced2024-10-22: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: mass spectrometry, acute myeloid leukemia, immunotherapy, immunopeptidomics, leukemic progenitor cells,HLA peptides
Contact List
Juliane S.Walz
contact affiliationDepartment of Peptide-based Immunotherapy, University and University Hospital Tübingen, Tübingen, Germany
contact emailjuliane.walz@med.uni-tuebingen.de
lab head
AnnikaNelde
contact affiliationDepartment of Peptide-based Immunotherapy, University and University Hospital Tübingen, Tübingen, Germany
contact emailannika.nelde@uni-tuebingen.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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