PXD038594-1

PXD038594 is an original dataset announced via ProteomeXchange.

Title	Proteomics analysis of different histologic subtypes of lung adenocarcinoma reveals a critical role of LRPAP1 in micropapillary pattern metastasis
Description	Lung adenocarcinomas differ in prognosis based on their histologic growth pattern. Micropapillary growth in lung adenocarcinoma is associated with a host of adverse prognostic factors, especially metastases. Metastasis is the major cause of high mortality in lung cancer. Exploring the underlying mechanisms of metastasis in the early stage thus holds promise for identifying new therapeutic strategies that may enhance survival. We applied quantitative mass spectrometry to compare protein expression profiles in different histologic subtypes, including adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), invasive adenocarcinoma (IAC) histologic subtype includes acinar (ACI), micropapillary (MIP). We discovered that low-density lipoprotein receptor–related protein–associated protein 1 (LRPAP1) has the highest protein level in MIP, which was confirmed by immunohistochemistry (IHC). The co-expressed proteins in our data like PSMD1 and HSP90AB1 were also reported they are high-expressed in cancer and have important role in metastasis. Overexpressed LRPAP1 promoted migration of lung cancer cells in vitro. Our findings suggest that LRPAP1 plays an important role in promoting lung cancer cell metastasis, and may act as a novel target for anti-metastatic therapy.
HostingRepository	iProX
AnnounceDate	2022-12-07
AnnouncementXML	Submission_2023-10-19_22:53:24.709.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Haojie Yan
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	methionine oxidation with neutral loss of 64 Da
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-12-06 18:51:15	ID requested
⏵ 1	2023-10-19 22:53:25	announced
2	2024-02-25 22:04:08	announced	2024-02-26: Update information.

Dataset with its publication pending

submitter keyword: Proteomics

Furong Li
contact affiliation	Shenzhen People's Hospital (The Second Clinical Medical College of Jinan University; The First Afliated Hospital, Southern University of Science and Technology)
contact email	lifurong@mail.sustech.edu.cn
lab head
Haojie Yan
contact affiliation	Shenzhen People's Hospital (The Second Clinical Medical College of Jinan University; The First Afliated Hospital, Southern University of Science and Technology)
contact email	yanhaojie1989@126.com
dataset submitter

iProX dataset URI