PXD038532-1

PXD038532 is an original dataset announced via ProteomeXchange.

Title	HIC1 interacts with FOXP3 multi protein complex: a novel mechanism to regulate human regulatory T cell differentiation and function
Description	Transcriptional repressor, hypermethylated in cancer 1 (HIC1) is an important contributor to regulatory T (Treg) cell development and function. To investigate the mechanism by which it regulates Treg cell development, we systematically characterized the HIC1 interactome by affinity-purification mass spectrometry in human regulatory T cells. Interactors, involved in protein transport, mRNA processing, non-coding (ncRNA) transcription and RNA metabolism processes were identified. These data demonstrate that HIC1 is a part of a FOXP3-RUNX1-CBFβ protein complex that regulates Treg signature genes and is indispensable for the suppressive function of FOXP3+ regulatory T cells.
HostingRepository	PanoramaPublic
AnnounceDate	2023-10-16
AnnouncementXML	Submission_2023-10-16_10:05:34.064.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	supported by repository but incomplete data and/or metadata
PrimarySubmitter	Robert Moulder
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	Carbamidomethyl; Label:13C(6)15N(2); Label:13C(6)15N(4); Label:13C(6)15N(1)
Instrument	TSQ Vantage

Revision	Datetime	Status	ChangeLog Entry
0	2022-12-04 13:02:43	ID requested
⏵ 1	2023-10-16 10:05:34	announced

Andrabi SBA, Batkulwar K, Bhosale SD, Moulder R, Khan MH, Buchacher T, Khan MM, Arnkil I, Rasool O, Marson A, Kalim UU, Lahesmaa R, HIC1 interacts with FOXP3 multi protein complex: Novel pleiotropic mechanisms to regulate human regulatory T cell differentiation and function. Immunol Lett, 263():123-132(2023) [pubmed]

submitter keyword: FOXP3+ regulatory T cells, hypermethylated in cancer 1 (HIC1), interactome

Riitta Lahesmaa
contact affiliation	Turku Bioscience
contact email	rilahes@utu.fi
lab head
Robert Moulder
contact affiliation	Turku Bioscience
contact email	robmou@utu.fi
dataset submitter

Panorama Public dataset URI