<<< Full experiment listing


PXD038532 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHIC1 interacts with FOXP3 multi protein complex: a novel mechanism to regulate human regulatory T cell differentiation and function
DescriptionTranscriptional repressor, hypermethylated in cancer 1 (HIC1) is an important contributor to regulatory T (Treg) cell development and function. To investigate the mechanism by which it regulates Treg cell development, we systematically characterized the HIC1 interactome by affinity-purification mass spectrometry in human regulatory T cells. Interactors, involved in protein transport, mRNA processing, non-coding (ncRNA) transcription and RNA metabolism processes were identified. These data demonstrate that HIC1 is a part of a FOXP3-RUNX1-CBFβ protein complex that regulates Treg signature genes and is indispensable for the suppressive function of FOXP3+ regulatory T cells.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportsupported by repository but incomplete data and/or metadata
PrimarySubmitterRobert Moulder
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListCarbamidomethyl; Label:13C(6)15N(2); Label:13C(6)15N(4); Label:13C(6)15N(1)
InstrumentTSQ Vantage
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-12-04 13:02:43ID requested
12023-10-16 10:05:34announced
Publication List
Andrabi SBA, Batkulwar K, Bhosale SD, Moulder R, Khan MH, Buchacher T, Khan MM, Arnkil I, Rasool O, Marson A, Kalim UU, Lahesmaa R, HIC1 interacts with FOXP3 multi protein complex: Novel pleiotropic mechanisms to regulate human regulatory T cell differentiation and function. Immunol Lett, 263():123-132(2023) [pubmed]
Keyword List
submitter keyword: FOXP3+ regulatory T cells, hypermethylated in cancer 1 (HIC1), interactome
Contact List
Riitta Lahesmaa
contact affiliationTurku Bioscience
contact emailrilahes@utu.fi
lab head
Robert Moulder
contact affiliationTurku Bioscience
contact emailrobmou@utu.fi
dataset submitter
Full Dataset Link List
Panorama Public dataset URI