PXD038437-2
PXD038437 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteogenomic landscape of multiple myeloma |
Description | Multiple myeloma is a plasma cell malignancy of the bone marrow. Despite therapeutic advances, multiple myeloma remains incurable and better risk stratification as well as new therapies are therefore highly needed. The proteome of multiple myeloma has not been systematically assessed before and holds the potential to uncover additional insight into disease biology and improved prognostic models. Here, we provide a comprehensive multi-omics analysis including deep tandem mass tags (TMT)-based quantitative global (phospho)proteomics, RNA sequencing and nanopore DNA sequencing of 138 primary patient-derived plasma cell malignancies encompassing treatment-naive multiple myeloma patients treated in clinical trials, plasma cell leukemia, and the premalignancy monoclonal gammopathy of undetermined significance (MGUS), as well as healthy controls. We found that the (phospho)proteome of malignant plasma cells is highly deregulated as compared to healthy plasma cells and is both defined by chromosomal alterations and extensive post-transcriptional regulation. A protein signature was identified that is associated with aggressive disease and more predictive for outcome than cytogenetic-based risk assessment in newly diagnosed multiple myeloma. Integration with functional genetics and single-cell sequencing revealed generally and genetic subtype-specific deregulated proteins and pathways in plasma cell malignancies that include novel potential targets for (immuno)therapies. These findings provide new insights in the biology of multiple myeloma and will be a unique resource for investigating new therapeutic approaches. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:49:38.974.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Evelyn Ramberger |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | phosphorylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF-X |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2022-11-27 00:08:39 | ID requested | |
1 | 2024-07-12 08:36:13 | announced | |
⏵ 2 | 2024-10-22 06:49:39 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1038/s43018-024-00784-3; |
Ramberger E, Sapozhnikova V, Ng YLD, Dolnik A, Ziehm M, Popp O, Str, ä, ng E, Kull M, Gr, ü, nschl, ä, ger F, Kr, ü, ger J, Benary M, M, ü, ller S, Gao X, Murgai A, Haji M, Schmidt A, Lutz R, Nogai A, Braune J, Laue D, Langer C, Khandanpour C, Bassermann F, D, ö, hner H, Engelhardt M, Straka C, Hundemer M, Beule D, Haas S, Keller U, Einsele H, Bullinger L, Knop S, Mertins P, Kr, ö, nke J, The proteogenomic landscape of multiple myeloma reveals insights into disease biology and therapeutic opportunities. Nat Cancer, 5(8):1267-1284(2024) [pubmed] |
Keyword List
submitter keyword: multiple myeloma, proteogenomics, plasma cells, therapeutic targets, clinical proteomics, risk signatures, biomarkers |
Contact List
Philipp Mertins | |
---|---|
contact affiliation | Proteomics Platform, Max Delbrück Center for Molecular Medicine, Berlin, Germany |
contact email | Philipp.Mertins@mdc-berlin.de |
lab head | |
Evelyn Ramberger | |
contact affiliation | Max Delbrück Center for Molecular Medicine, Berlin |
contact email | evelyn.ramberger@mdc-berlin.de |
dataset submitter |
Full Dataset Link List
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PRIDE project URI |
Repository Record List
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