PXD038403 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Temporal landscape of mitochondrial proteostasis governed by the UPRmt |
Description | When mitochondrial proteostasis breaks down, quality control pathways including the UPRmt and PINK1/Parkin mitophagy are activated in response. However, beyond the upregulation of chaperones and proteases, we have a limited understanding of how the UPRmt remodels and restores damaged mito-proteomes. Here, we have developed a functional proteomics framework, termed MitoPQ (Mitochondrial Proteostasis Quantification), to dissect the UPRmt’s role in maintaining proteostasis during stress. We discover essential roles for the UPRmt in both protecting and repairing proteostasis, with oxidative phosphorylation metabolism being a central target of the UPRmt. Transcriptome analyses together with MitoPQ reveal that UPRmt transcription factors drive independent signaling arms that act in concert to maintain proteostasis. Unidirectional interplay between the UPRmt and PINK1/Parkin mitophagy was found to promote oxidative phosphorylation recovery when the UPRmt failed. Collectively, this study defines the network of proteostasis mediated by the UPRmt and highlights the value of functional proteomics in decoding stressed proteomes. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:24:01.609.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Joel Steele |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-11-26 04:13:37 | ID requested | |
1 | 2023-09-26 23:55:53 | announced | |
⏵ 2 | 2023-11-14 08:24:02 | announced | 2023-11-14: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: mitochondria |
metabolism |
OXPHOS |
proteostasis |
UPRmt |
mitophagy |
PINK1 |
Parkin |
Contact List
Michael Lazarou |
contact affiliation | Walter and Eliza Hall Institute of Medical Research, co-affiliated with Monash University |
contact email | m.lazarou@wehi.edu.au |
lab head | |
Joel Steele |
contact affiliation | Monash |
contact email | joel.steele@monash.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD038403
- Label: PRIDE project
- Name: Temporal landscape of mitochondrial proteostasis governed by the UPRmt