PXD038357-1
PXD038357 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Lysine Succinylation of VBS Contributes to Sclerotia Development and Aflatoxin Biosynthesis in Aspergillus flavus |
| Description | a quantification method was performed based on tandem mass tag (TMT) labeling and antibody based affinity enrichment of succinylated peptides using high accuracy nano-LC-MS/MS, to explore the portential mechanism of succinylation in affecting the pathogenicity of naturally isolated A. flavus strains with different toxin production. Altogether, 1,240 lysine succinylation sites in 768 proteins were identified with 1,103 lysine succinylation sites in 685 proteins quantified. Comparing the levels of succinylated proteins between high and low aflatoxin-producing A. flavus strains, bioinformatics analysis indicated that almost all succinylated proteins located in the aflatoxin biosynthetic pathway were down-regulated, and these succinylations directly affected the synthesis of aflatoxins. |
| HostingRepository | iProX |
| AnnounceDate | 2022-11-25 |
| AnnouncementXML | Submission_2022-11-25_02:00:38.820.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yu Wang |
| SpeciesList | scientific name: Aspergillus flavus NRRL3357; NCBI TaxID: 332952; |
| ModificationList | N6-succinyl-L-lysine |
| Instrument | Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-11-25 02:00:27 | ID requested | |
| ⏵ 1 | 2022-11-25 02:00:39 | announced | |
| 2 | 2023-02-06 19:16:41 | announced | 2023-02-07: Update publication information. |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Aspergillus flavus, lysine succinylation, quantification proteome, natural environments, aflatoxin production |
Contact List
| Rui Hu | |
|---|---|
| contact affiliation | Institute of Wuhan Physics and Mathematics, Chinese Academy of Science |
| contact email | hurui@apm.ac.cn |
| lab head | |
| Yu Wang | |
| contact affiliation | Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences |
| contact email | wangyu@apm.ac.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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