PXD038238-2

PXD038238 is an original dataset announced via ProteomeXchange.

Title	Bacteria Commonly Associated with Central Nervous System Catheter Infections Elicit Distinct CSF Proteome Signatures
Description	Cerebrospinal fluid (CSF) shunt infection is a common and devastating complication of the treatment of hydrocephalus. Timely and accurate diagnosis is essential as these infections can lead to long term neurologic consequences like seizures, decreased IQ and impaired school performance. Currently the diagnosis of shunt infection relies on bacterial culture, however, culture is not always accurate especially as these infections are frequently caused by bacteria capable of forming biofilms like Staphylococcus epidermidis, Cutibacterium acnes, and Pseudomonas aeruginosa and may have very few planktonic bacteria in the CSF to be picked up on culture. Therefore, there is a critical need to identify a new rapid, and accurate method for diagnosis of CSF shunt infection with broad bacterial species coverage to improve the long-term outcomes of children suffering from these infections.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:59:50.901.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ishwor Thapa
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2022-11-21 16:14:22	ID requested
1	2023-01-30 10:33:04	announced
⏵ 2	2023-11-14 08:59:51	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: inflammation, P. aeruginosa, central nervous system infection, CNS, CSF, infection,Shunt infection, proteome, S. epidermidis, biomarker, C. acnes

Dr. Gwenn L. Skar
contact affiliation	Department of Pediatrics University of Nebraska Medical Center, Omaha, NE
contact email	gskar@unmc.edu
lab head
Ishwor Thapa
contact affiliation	University of Nebraska at Omaha
contact email	ithapa@unomaha.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/01/PXD038238

PRIDE project URI

• PRIDE
  1. PXD038238
     1. Label: PRIDE project
     2. Name: Bacteria Commonly Associated with Central Nervous System Catheter Infections Elicit Distinct CSF Proteome Signatures