PXD038030-1
PXD038030 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Unperturbed dormancy recording reveals stochastic awakening strategies in endocrine treated breast cancer cells |
Description | Hormone dependent breast cancer (HDBC) is the most commonly diagnosed tumor type in women. Adjuvant endocrine therapies (ET) have been the cornerstone in the clinical management of HDBC patients for over forty years. A vast proportion of HDBC patients incur long periods of clinical dormancy following ET, with tumour awakening appearing at a steady pace for up to 25 years (Pan et al., 2017). Extensive genomic studies have demonstrated that 15-30% of clinical relapses develop recurrent genomic changes which contribute to drug resistance (i.e. ESR1 activating mutations) (Bertucci et al., 2019; Magnani et al., 2017; Razavi et al., 2018). However, even in these cases, there is no conclusive evidence around the pre-existence vs. de novo nature of these events. Here, we analyzed histone PTMs in dormant and awakened breast cancer cells treated with endocrine therapy. |
HostingRepository | PRIDE |
AnnounceDate | 2024-05-23 |
AnnouncementXML | Submission_2024-05-23_01:11:28.594.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Roberta Noberini |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monomethylated residue; acetylated residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2022-11-07 10:21:58 | ID requested | |
⏵ 1 | 2024-05-23 01:11:29 | announced |
Publication List
10.1158/2159-8290.cd-23-1161; |
Rosano D, Sofyali E, Dhiman H, Ghirardi C, Ivanoiu D, Heide T, Vingiani A, Bertolotti A, Pruneri G, Canale E, Dewhurst HF, Saha D, Slaven N, Barozzi I, Li T, Zemlyanskiy G, Phillips H, James C, Gy, ő, rffy B, Lynn C, Cresswell GD, Rehman F, Noberini R, Bonaldi T, Sottoriva A, Magnani L, Long-term Multimodal Recording Reveals Epigenetic Adaptation Routes in Dormant Breast Cancer Cells. Cancer Discov, 14(5):866-889(2024) [pubmed] |
Keyword List
submitter keyword: Histone PTMs, epigenetics, dormancy |
Contact List
Tiziana Bonaldi | |
---|---|
contact affiliation | European Institute of Oncology, Milan, Italy |
contact email | tiziana.bonaldi@ieo.it |
lab head | |
Roberta Noberini | |
contact affiliation | Istituto Europeo di Oncologia |
contact email | roberta.noberini@ieo.it |
dataset submitter |
Full Dataset Link List
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD038030 |
PRIDE project URI |
Repository Record List
[ + ]