PXD038003-1
PXD038003 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Treatment choice matters in multiple sclerosis: The role of extracellular vesicles in predicting treatment response. |
| Description | Multiple sclerosis (MS) is an immune-mediated central nervous system disease whose course is unpredictable. Finding biomarkers that help to better comprehend thedisease’s pathogenesis iscrucial for supporting clinical decision-making. Blood extracellular vesicles (EVs) are membrane-bound particles secreted by all cell types that contain information on the disease’s pathological processes.This study aimed to identify the immune and nervous system-associated EV profile in blood that could have a specific role as biomarker in MS. We also assessed the possible correlation between this EV profile with disease activity and cognitive and motor dysfunction in patients with MS. For this propose, we analyzed the levels, diameter and protein content of circulating nervous and immune system-derived EVs in the blood of patients with MS compared to the EVs found in another immune-mediated disease (rheumatoid arthritis) and in another white matter lesion (subcortical stroke) to determine the contribution of these EVs to autoimmunity and brain damage. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-10-20 |
| AnnouncementXML | Submission_2025-10-19_17:57:34.885.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Susana Bravo |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | TripleTOF 6600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-11-07 09:44:30 | ID requested | |
| ⏵ 1 | 2025-10-19 17:57:35 | announced |
Publication List
| 10.1212/nxi.0000000000200483; |
| Torres Iglesias G, Chavarr, í, a-Miranda A, L, ó, pez-Molina M, Del Fresno C, Mata-Mart, í, nez P, Nozal P, Chico-Garcia JL, Fern, á, ndez-Fournier M, Lacruz Ballester L, Sanchez D, Montero-Calle A, Barderas R, Bravo S, Puertas I, York E, D, í, ez-Tejedor E, Guti, é, rrez-Fern, á, ndez M, Otero-Ortega L, Extracellular Vesicles as Novel Biomarkers for Tumor Association in Intermediate-Risk Paraneoplastic Neurologic Syndromes. Neurol Neuroimmunol Neuroinflamm, 12(6):e200483(2025) [pubmed] |
Keyword List
| submitter keyword: Rheumatoid Arthritis |
| Subcortical Stroke.icles, Blood |
| Exosomes |
| Extracellular Vesicles |
| Multiple Sclerosis |
| Proteomic Analysis, Extracellular VesBiomarkers, Intracerebral Hemorrhage, Rat, Proteomics,Blood |
Contact List
| Susana Bravo | |
|---|---|
| contact affiliation | Instituto de Investigaciones Sanitarias de Santiago de Compostela |
| contact email | sbbravo@gmail.com |
| lab head | |
| Susana Bravo | |
| contact affiliation | FIDIS |
| contact email | sbbravo@gmail.com |
| dataset submitter | |
Full Dataset Link List
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD038003 |
| PRIDE project URI |
Repository Record List
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