PXD037973-1
PXD037973 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteolysis-assisted cyclization facilitates site-centric target deconvolution of isothiocyanates |
| Description | Here we report an unexpected chemistry through which ITC-protein adduct forms a stable N-terminal dihydrothiazole peptide adduct during proteolysis. This proteolysis-assisted cyclization (PAC) reaction can be harnessed for developing affinity-based and activity-based chemoproteomic methods to site-specifically profile targets of ITCs. |
| HostingRepository | iProX |
| AnnounceDate | 2022-11-07 |
| AnnouncementXML | Submission_2022-11-07_00:19:43.704.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jingyang He |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF-X; Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-11-07 00:12:55 | ID requested | |
| ⏵ 1 | 2022-11-07 00:19:44 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Isothiocyanates, N-terminal dihydrothiazole peptide adduct |
Contact List
| Jing Yang | |
|---|---|
| contact affiliation | National Center for Protein Sciences (PHOENIX, Beijing) |
| contact email | yangjing@ncpsb.org.cn |
| lab head | |
| Jingyang He | |
| contact affiliation | National Center for Protein Sciences (PHOENIX, Beijing) |
| contact email | jingyang310047@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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