PXD037814-1

PXD037814 is an original dataset announced via ProteomeXchange.

Title	Lysergic acid dethylamide proteomics modulation in brain organoids
Description	Lysergic acid diethylamide (LSD), considered the prototypical psychedelic molecule, has effects on consciousness and perception. However, the molecular mechanisms involved in LSD effects in human neural cells and how they may be translated into changes in physiology are still poorly understood. Here we used human cerebral organoids as a biological live model to explore the response of human brain cells to LSD. Mass spectrometry-based proteomics was performed to gain insights on molecular targets and signaling pathways involved in the mid and long-term effects of LSD.
HostingRepository	PRIDE
AnnounceDate	2024-10-17
AnnouncementXML	Submission_2024-10-17_03:33:37.811.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Juliana Minardi Nascimento
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2022-10-28 07:38:27	ID requested
⏵ 1	2024-10-17 03:33:38	announced

N Costa M, Goto-Silva L, M Nascimento J, Domith I, Karmirian K, Feilding A, Trindade P, Martins-de-Souza D, K Rehen S, LSD Modulates Proteins Involved in Cell Proteostasis, Energy Metabolism and Neuroplasticity in Human Cerebral Organoids. ACS Omega, 9(34):36553-36568(2024) [pubmed]

10.1021/acsomega.4c04712;

submitter keyword: cerebral organoid,iPSC, neural cell, proteome

Daniel Martins-de-Souza
contact affiliation	Lab of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil
contact email	dmsouza@unicamp.br
lab head
Juliana Minardi Nascimento
contact affiliation	University of Campinas
contact email	juminardi@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD037814

PRIDE project URI

• PRIDE
  1. PXD037814
     1. Label: PRIDE project
     2. Name: Lysergic acid dethylamide proteomics modulation in brain organoids