PXD037696-1

PXD037696 is an original dataset announced via ProteomeXchange.

Title	Don’t die like me: Which proteins are responsible for the selective neuronal vulnerability within the substantia nigra?
Description	A hallmark of Parkinson’s disease is the specific degeneration of dopaminergic neurons in the substantia nigra pars compacta. Interestingly, not all of these neurons are equally affected. Studies revealed that neurons located more ventrally within the substantia nigra pars compacta have a higher prevalence to degenerate than those located in the dorsal tier. Reasons for this selective neuronal vulnerability are still unknown. The objective of the present study was to gain a better understanding of molecular differences between these two neuronal subpopulations that can explain the selective neuronal vulnerability within the substantia nigra. For this, both neuronal subpopulations were specifically isolated with laser microdissection. Following, their proteome was analyzed via data independent acquisition mass spectrometry. The results of this study revealed a minor number of proteins that were either specific or differentially expressed in one of the examined neuronal subpopulations within the substantia nigra. These proteins are associated with the cytoskeleton, neuronal plasticity, or calcium homeostasis. With these findings a deeper understanding can be gained of the selective neuronal vulnerability within the substantia nigra and of protective mechanisms against neurodegeneration in specific neuronal subpopulations.
HostingRepository	PRIDE
AnnounceDate	2024-08-09
AnnouncementXML	Submission_2024-08-09_05:30:38.774.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Annika Guntermann
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-10-25 04:27:59	ID requested
⏵ 1	2024-08-09 05:30:39	announced
2	2024-10-22 06:54:08	announced	2024-10-22: Updated project metadata.

10.1371/journal.pone.0296730;

10.1016/j.dib.2019.103711;

Steinbach S, Molina M, Grinberg LT, Aring L, Guntermann A, Marcus K, Heinsen H, Paraizo Leite RE, May C, Don't die like me: Which proteins are responsible for the selective neuronal vulnerability within the substantia nigra? PLoS One, 19(7):e0296730(2024) [pubmed]

Steinbach S, Serschnitzki B, Gerlach M, Marcus K, May C, proteome data set for use as a spectral library for protein modelling and protein mapping. Data Brief, 23():103711(2019) [pubmed]

ProteomeXchange project tag: Human Brain Proteome Project (HUPO_HBPP) (B/D-HPP)

submitter keyword: neurons, mass spectrometry, proteomic,selective neuronal vulnerability, substantia nigra

Caroline May
contact affiliation	Medizinisches Proteom-Center Gesundheitscampus 4 44801 Bochum
contact email	Caroline.May@rub.de
lab head
Annika Guntermann
contact affiliation	Medizinisches Proteom-Center
contact email	Annika.Guntermann@rub.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD037696

PRIDE project URI

• PRIDE
  1. PXD037696
     1. Label: PRIDE project
     2. Name: Don’t die like me: Which proteins are responsible for the selective neuronal vulnerability within the substantia nigra?