PXD037696 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Don’t die like me: Which proteins are responsible for the selective neuronal vulnerability within the substantia nigra? |
Description | A hallmark of Parkinson’s disease is the specific degeneration of dopaminergic neurons in the substantia nigra pars compacta. Interestingly, not all of these neurons are equally affected. Studies revealed that neurons located more ventrally within the substantia nigra pars compacta have a higher prevalence to degenerate than those located in the dorsal tier. Reasons for this selective neuronal vulnerability are still unknown. The objective of the present study was to gain a better understanding of molecular differences between these two neuronal subpopulations that can explain the selective neuronal vulnerability within the substantia nigra. For this, both neuronal subpopulations were specifically isolated with laser microdissection. Following, their proteome was analyzed via data independent acquisition mass spectrometry. The results of this study revealed a minor number of proteins that were either specific or differentially expressed in one of the examined neuronal subpopulations within the substantia nigra. These proteins are associated with the cytoskeleton, neuronal plasticity, or calcium homeostasis. With these findings a deeper understanding can be gained of the selective neuronal vulnerability within the substantia nigra and of protective mechanisms against neurodegeneration in specific neuronal subpopulations. |
HostingRepository | PRIDE |
AnnounceDate | 2024-08-09 |
AnnouncementXML | Submission_2024-08-09_05:30:38.774.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Annika Guntermann |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-10-25 04:27:59 | ID requested | |
⏵ 1 | 2024-08-09 05:30:39 | announced | |
2 | 2024-10-22 06:54:08 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1371/journal.pone.0296730; |
10.1016/j.dib.2019.103711; |
Steinbach S, Molina M, Grinberg LT, Aring L, Guntermann A, Marcus K, Heinsen H, Paraizo Leite RE, May C, Don't die like me: Which proteins are responsible for the selective neuronal vulnerability within the substantia nigra? PLoS One, 19(7):e0296730(2024) [pubmed] |
Steinbach S, Serschnitzki B, Gerlach M, Marcus K, May C, proteome data set for use as a spectral library for protein modelling and protein mapping. Data Brief, 23():103711(2019) [pubmed] |
Keyword List
ProteomeXchange project tag: Human Brain Proteome Project (HUPO_HBPP) (B/D-HPP) |
submitter keyword: neurons, mass spectrometry, proteomic,selective neuronal vulnerability, substantia nigra |
Contact List
Caroline May |
contact affiliation | Medizinisches Proteom-Center Gesundheitscampus 4 44801 Bochum |
contact email | Caroline.May@rub.de |
lab head | |
Annika Guntermann |
contact affiliation | Medizinisches Proteom-Center |
contact email | Annika.Guntermann@rub.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD037696
- Label: PRIDE project
- Name: Don’t die like me: Which proteins are responsible for the selective neuronal vulnerability within the substantia nigra?