PXD037653-2

PXD037653 is an original dataset announced via ProteomeXchange.

Title	Fraisinib: a calix[4]pyrrole derivative effective in reducing NSCLC tumor in-vivo, is found to act as ligand of the Glycine-tRNA Synthase (GARS1), a new molecular target in oncology.
Description	Adopting a multi-proteomic approach, we evaluated the possible involvement of GARS1 in the regulation of phenotypic alterations that reduced in vivo tumorigenicity of A549 cells exposed to Fraisinib over time. For this purpose, we performed a differential proteomic analysis followed by the generation of functional networks and enrichment analysis, and then we compared the obtained results after including the known GARS1 interactors identified in A549 cell line.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:24:06.545.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Gabriela Coronel Vargas
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-10-24 00:57:01	ID requested
1	2024-01-20 04:27:12	announced
⏵ 2	2024-10-22 06:24:06	announced	2024-10-22: Updated project metadata.

10.3389/FPHAR.2023.1258108;

submitter keyword: Human, cancer, chemioterapy, GARS1, lung

Camillo Rosano
contact affiliation	IRCCS Ospedale Policlinico San Martino, Genova, Italy
contact email	camillo.rosano@hsanmartino.it
lab head
Gabriela Coronel Vargas
contact affiliation	IRCCS Ospedale Policlinico San Martino, Genova
contact email	gabrielafernanda.coronelvargas@edu.unige.it
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD037653

PRIDE project URI

• PRIDE
  1. PXD037653
     1. Label: PRIDE project
     2. Name: Fraisinib: a calix[4]pyrrole derivative effective in reducing NSCLC tumor in-vivo, is found to act as ligand of the Glycine-tRNA Synthase (GARS1), a new molecular target in oncology.