PXD037643-1

PXD037643 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Lipo-chitooligosaccharides induce specialized fungal metabolite profiles that modulate bacterial growth.
Description	Lipo-chitooligosaccharides (LCOs) are historically known for their role as microbial-derived signaling molecules that shape plant symbiosis with beneficial rhizobia or mycorrhizal fungi. Recent studies showing that LCOs are widespread across the fungal kingdom have raised questions about the ecological function of these compounds in organisms that do not form symbiotic relationships with plants. To elucidate the ecological function of these compounds, we investigate the metabolomic response of the ubiquitous human pathogen, Aspergillus fumigatus, to LCOs. Our metabolomics data revealed that exogenous application of various types of LCOs to A. fumigatus resulted in significant shifts in fungal metabolic profile, with marked changes in the production of specialized metabolites known to mediate ecological interactions. Using network analyses, we identify specific types of LCOs with the most significant effect on the abundance of known metabolites. Extracts of several LCO-induced metabolic profiles significantly impact the growth rates of diverse bacterial species. These findings suggest that LCOs may play an important role in the competitive dynamics of non-plant-symbiotic fungi and bacteria. This study identifies specific metabolomic profiles induced by these ubiquitously produced chemicals and creates a foundation for future studies into the potential roles of LCOs as modulators of interkingdom competition.
HostingRepository	MassIVE
AnnounceDate	2022-11-22
AnnouncementXML	Submission_2022-11-22_12:55:44.862.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tomas Allen Rush
SpeciesList	scientific name: Aspergillus fumigatus Af293; NCBI TaxID: 330879;
ModificationList	unknown modification
Instrument	instrument model

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-10-21 11:52:11	ID requested
⏵ 1	2022-11-22 12:55:45	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: Lipo-chitooligosaccharides, secondary metabolites, synergism, biosynthetic gene clusters, bacteria, Aspergillus, network analyses

submitter keyword: Lipo-chitooligosaccharides, secondary metabolites, synergism, biosynthetic gene clusters, bacteria, Aspergillus, network analyses

Contact List

Tomas Allen Rush
contact affiliation	Oak Ridge National Laboratory
contact email	rushta@ornl.gov
lab head
Tomas Allen Rush
contact affiliation	Oak Ridge National Laboratory
contact email	rushta@ornl.gov
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000090566/