PXD037621-1

PXD037621 is an original dataset announced via ProteomeXchange.

Title	BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells
Description	To clarify the potential BLIMP1 downstream target regulating PD-L1 expression, we performed proteomics analysis using BLIMP1 Hep3B cells and control cells. Proteomics analysis revealed that SPI1 may serve as a pivotal transcriptional factor that enhances PD-L1 expression by acting as a downstream effector of BLIMP1.
HostingRepository	PRIDE
AnnounceDate	2022-11-23
AnnouncementXML	Submission_2022-11-22_23:29:19.409.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	xuehaowang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-10-20 13:29:39	ID requested
⏵ 1	2022-11-22 23:29:19	announced
2	2023-11-14 08:59:42	announced	2023-11-14: Updated project metadata.

submitter keyword: transcriptional activation, post-translational modification, T cell exhaustion, hepatocellular carcinoma,immunotherapy

XuehaoWang
contact affiliation	Nanjing Medical University
contact email	wangxh@njmu.edu.cn
lab head
xuehaowang
contact affiliation	Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University; Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences; NHC Key Laboratory of Living Donor Liver Transplantation (Nanjing Medical University), Nanjing, Jiangsu Province, China.
contact email	wangxh@njmu.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/11/PXD037621

PRIDE project URI

• PRIDE
  1. PXD037621
     1. Label: PRIDE project
     2. Name: BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells