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PXD037580-1

PXD037580 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	DeepFLR Facilitates False Localization Rate Control in Phosphoproteomics
Description	Site-specific phosphorylation events affect nearly all the cellular processes and correct phosphosite localization plays an important role in biological or medical health studies. However, direct false localization rate (FLR) control remains challenging in phosphoproteomics. Here, we propose DeepFLR, a deep learning-based framework utilizing spectrum prediction and the target-decoy method for FLR estimation. We demonstrate that the similarity between predicted and experimental phosphopeptide spectra is comparable to the measurement reproducibility. We further benchmark our method with four synthetic datasets and three real biological sample datasets, showcasing its ability for sensitive phosphosite localization with accurate FLR estimation.
HostingRepository	iProX
AnnounceDate	2022-10-20
AnnouncementXML	Submission_2023-04-03_20:08:07.593.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yu Zong
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-10-20 01:06:51	ID requested
⏵ 1	2023-04-03 20:08:07	announced
2	2023-04-24 19:45:44	announced	2023-04-25: Update publication information.

Publication List

Dataset with its publication pending

Keyword List

submitter keyword: DeepFLR, FLR, Phosphorylation

Contact List

Liang Qiao
contact affiliation	Fudan University
contact email	liang_qiao@fudan.edu.cn
lab head
Yu Zong
contact affiliation	Fudan University
contact email	20110220128@fudan.edu.cn
dataset submitter

Full Dataset Link List

iProX dataset URI