PXD037579-1

PXD037579 is an original dataset announced via ProteomeXchange.

Title	IL-17A and TNF-α inhibitors induce multiple molecules andsignal pathway change in psoriasis
Description	Adalimumab and secukinumab are commonly used for moderate-severe psoriasis vulgaris (PV), but distinct individual response and impaired effectiveness happen occasionally. Little is known about it. Here, we report a proteomic analysis of psoriatic lesions from patients treated with these drugs using Data Independent Acquisition Mass Spectrometry (DIA-MS). Thousands of differentially expressed proteins (DEPs) changed over 12 weeks of treatment. Network analysis showed DEPs could interact and induce transformation in matrix components, metabolic regulation, and immune response. PRM analysis suggested S100s, STAT1, KRT2, TYMP, SOD2, HSP90AB1, TFRC, and COL5A1 were the most significantly changed proteins in both groups. There is a positively association between the psoriasis area and severity index (PASI) score and three proteins (TFRC, IMPDH2, KRT2). Our study suggests that inhibition of IL-17A and TNF-α can induce multiple molecules change in psoriatic lesions and overlapping effect on immune response and proces
HostingRepository	iProX
AnnounceDate	2022-10-20
AnnouncementXML	Submission_2022-10-19_20:09:21.387.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Qiang Dong
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2022-10-19 20:09:08	ID requested
⏵ 1	2022-10-19 20:09:21	announced
2	2022-12-13 01:41:46	announced	2022-12-13: Update publication information.

Dataset with its publication pending

submitter keyword: Proteomics, Psoriasis, Parallel Reaction Monitoring, Data-Independent Acquisition Mass Spectrometry, Biological Agent, Ingenuity Pathway Analysis

Qiang Dong
contact affiliation	Dermatology Hospital of Zhejiang Province
contact email	QiangDong.edu@outlook.com
lab head
Qiang Dong
contact affiliation	Dermatology Hospital of Zhejiang Province
contact email	QiangDong.edu@outlook.com
dataset submitter

iProX dataset URI