PXD037534-1

PXD037534 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	A novel YDDX linear motif mediates docking of the IKK kinase to substrates: structural and functional insights
Description	The inhibitor of kB kinase (IKK) is the master regulator of the nuclear factor kB (NF-kB) pathway, involved in inflammatory, immune and apoptotic responses. In the ‘canonical’ NF-kB pathway, IKK phosphorylates inhibitor of kB (IkB) proteins and this triggers ubiquitin-mediated degradation of IkB, leading to release and nuclear translocation of NF-B transcription factors. The data presented show that the IKK and IKK subunits recognize a YDDX docking site located within the disordered C-terminal region of IkBa. Our results also suggest that IKK contributes to the docking interaction with higher affinity as compared to IKK.
HostingRepository	jPOST
AnnounceDate	2024-05-09
AnnouncementXML	Submission_2024-05-08_08:00:19.981.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD037534
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Francis O'Reilly
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-10-18 18:08:02	ID requested
⏵ 1	2024-05-08 08:00:20	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: crosslinking MS, IKKbeta, IkB peptide

submitter keyword: crosslinking MS, IKKbeta, IkB peptide

Contact List

Juri Rappsilber
lab head
Francis O'Reilly
contact affiliation	NCI-NIH
dataset submitter

Full Dataset Link List

jPOST dataset URI
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jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST001892/