PXD037524-1

PXD037524 is an original dataset announced via ProteomeXchange.

Title	Myeloperoxidase is a Critical Mediator of Anthracycline-induced Cardiomyopathy
Description	The anthracycline doxorubicin is a commonly used chemotherapeutic drug that induces cardiomyopathy in almost 10% of patients. The aim of this study was to examine the role of the leukocyte-derived enzyme Myeloperoxidase (MPO) in pathogenesis of anthracycline-induced Cardiomyopathy (AICM). We performed proteomics on whole heart tissue of MPO-deficient mice on C57BL/6J background and wildtype (WT) littermates seven days after intravenous injection of the anthracycline Doxorubicin (20 mg/kg bodyweight, dissolved in saline) or saline (NaCl).
HostingRepository	PRIDE
AnnounceDate	2023-08-30
AnnouncementXML	Submission_2023-08-30_01:08:54.686.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	PreranaWagle
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2022-10-18 08:02:09	ID requested
⏵ 1	2023-08-30 01:08:55	announced

Dataset with its publication pending

submitter keyword: cardiotoxicity, polymorphonuclear neutrophils, AICM, MPO,Doxorubicin

MartinMollenhauer
contact affiliation	Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany
contact email	martin.mollenhauer@uk-koeln.de
lab head
PreranaWagle
contact affiliation	CECAD Research Center
contact email	proteomics-facility@uni-koeln.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/08/PXD037524

PRIDE project URI

• PRIDE
  1. PXD037524
     1. Label: PRIDE project
     2. Name: Myeloperoxidase is a Critical Mediator of Anthracycline-induced Cardiomyopathy