PXD037514-1
PXD037514 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Comprehensive and quantitative analysis of the changes in proteomic and phosphoproteomic profiles during stimulation and repression of steroidogenesis in MA-10 Leydig cells. |
| Description | In the present study, we have used a quantitative LC-MS/MS approach using total and phosphopeptide-enriched proteins to identify the changes that occur in the proteome and phosphoproteome of MA-10 Leydig cells during both the stimulatory phase (Fsk/cAMP treatment) and inhibitory phase (AICAR-mediated activation of AMPK) of steroidogenesis. The phosphorylation level of several proteins, including some never before described in Leydig cells, was significantly altered during stimulation and inhibition of steroidogenesis. Our data provide new key insights into the finely tuned and dynamic processes that ensure adequate steroid hormone production. |
| HostingRepository | MassIVE |
| AnnounceDate | 2022-10-25 |
| AnnouncementXML | Submission_2022-10-25_04:56:28.869.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jacques J. Tremblay |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | Phospho |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-10-17 07:53:42 | ID requested | |
| ⏵ 1 | 2022-10-25 04:56:29 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Testis, Leydig cells, Steroidogenesis, Star, AMPK, Phosphoproteomics, Proteomics |
Contact List
| Jacques J. Trembay | |
|---|---|
| contact affiliation | CHU de Quebec Universite Laval |
| contact email | jacques-j.tremblay@crchudequebec.ulaval.ca |
| lab head | |
| Jacques J. Tremblay | |
| contact affiliation | Universite Laval |
| contact email | Jacques-J.Tremblay@crchudequebec.ulaval.ca |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000090539/ |
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