PXD037487 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Cellular quiescence uncouples the proteome from the transcriptome |
| Description | Neural stem cells (NSCs) are multipotent cells in the central nervous system which can self-renew, differentiate or reversibly exit the cell cycle to enter a dormat state known as quiescence. To study the molecular mechanisms underpinning this state we use an in vitro model of NSC quiescence, which uses adult hippocampal NSCs harvested from mice. In this cell culture system, we are able to reversibly induce quiescence by supplementing the media with BMP4. In this study we examine how the proteome changes as NSCs transition from an active state (proliferating, 0d BMP4) into quiescence (up to 21 days in BMP4). |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-03-09 |
| AnnouncementXML | Submission_2026-03-08_17:24:38.738.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Mark Skehel |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | TMT6plex-126 reporter+balance reagent acylated residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2022-10-17 01:27:28 | ID requested | |
| ⏵ 1 | 2026-03-08 17:24:39 | announced | |
Publication List
| 10.1038/s44318-026-00693-4; |
| Rossi A, Coum A, Madelenat M, Harris L, Strohbuecker S, Chai A, Fiaz H, Chaouni R, Faull P, Costello Heaven N, Grey W, Bonnet D, Hamid F, Makeyev EV, Snijders AP, Kelly G, Guillemot F, Sousa-Nunes R, Cellular quiescence uncouples the proteome from the transcriptome in neural stem cells. EMBO J, 45(5):1697-1727(2026) [pubmed] |
Keyword List
| submitter keyword: hippocampus, TMT, lc-ms/ms,Neural Stem cells |
Contact List
| Francois Guillemot |
|---|
| contact affiliation | The Francis Crick Institute 1 Midland Road London, NW1 1AT UK |
| contact email | Francois.Guillemot@crick.ac.uk |
| lab head | |
| Mark Skehel |
|---|
| contact affiliation | Francis Crick Institute |
| contact email | skehelm@crick.ac.uk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD037487 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD037487
- Label: PRIDE project
- Name: Cellular quiescence uncouples the proteome from the transcriptome
