PXD037391 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Oxidized thioredoxin-1 restrains the NLRP1 inflammasome |
| Description | To find cellular protein binding partners of the NLRP1 inflammasome, FLAG-tagged full length NLRP1 (or a GFP-FLAG protein control) was ectopically expressed in HEK 293T cells and affinity purified from cell lysates (Note: the NLRP1-FLAG-containing lysate samples were affinity purified in the presence or absence of excess proline) before proteins were reduced, alkylated, and trypsinized before TMT labelling and pooling of the differentially tested lysates to give three conditions (1. NLRP1-FLAG; 2. GFP-FLAG; 3. NLRP1-FLAG+proline) in duplicate. These data represent the results following sample and data processing. |
| HostingRepository | PRIDE |
| AnnounceDate | 2023-11-14 |
| AnnouncementXML | Submission_2023-11-14_08:59:04.303.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Daniel Ball |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2022-10-13 15:11:57 | ID requested | |
| 1 | 2022-11-04 11:18:37 | announced | |
| ⏵ 2 | 2023-11-14 08:59:04 | announced | 2023-11-14: Updated project metadata. |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: innate immunity, programmed cell death,inflammasome, chemical biology, pattern recognition receptors |
Contact List
| Daniel A. Bachovchin |
|---|
| contact affiliation | Department of Chemical Biology Memorial Sloan Kettering Cancer Center New York, NY |
| contact email | bachovcd@mskcc.org |
| lab head | |
| Daniel Ball |
|---|
| contact affiliation | Memorial Sloan Kettering Cancer Center |
| contact email | balld@mskcc.org |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/11/PXD037391 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD037391
- Label: PRIDE project
- Name: Oxidized thioredoxin-1 restrains the NLRP1 inflammasome
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