PXD037376 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Targeting CHAF1B enhances interferon activity in myeloproliferative neoplasms |
| Description | Interferons (IFNs) are cytokines with potent anti-neoplastic properties and significant clinical activity in the treatment of myeloproliferative neoplasms (MPNs). The use of pegylated IFN for the treatment of MPNs has been of particular interest, with several clinical trials establishing clinical responses. Here we demonstrate that chromatin assembly factor 1 subunit B (CHAF1B) is overexpressed in MPN patients. Targeted silencing of CHAF1B enhances transcription of IFN-stimulated genes and promotes IFN-dependent anti-neoplastic effects against MPN patient-derived cells. Our findings suggest that targeting CHAF1B in combination with IFN therapy may offer an avenue for the development of effective combination therapies for the treatment of MPNs. |
| HostingRepository | PRIDE |
| AnnounceDate | 2023-05-15 |
| AnnouncementXML | Submission_2023-05-15_06:18:43.868.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | RenuGoel |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ Orbitrap Elite |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2022-10-13 14:39:01 | ID requested | |
| ⏵ 1 | 2023-05-15 06:18:44 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: CHAF1B, myeloproliferative neoplasms, interferon |
Contact List
| Leonidas C.Platanias |
|---|
| contact affiliation | Robert H. Lurie Comprehensive Cancer Center |
| contact email | l-platanias@northwestern.edu |
| lab head | |
| RenuGoel |
|---|
| contact affiliation | Northwestern University |
| contact email | drrenugoel@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/05/PXD037376 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD037376
- Label: PRIDE project
- Name: Targeting CHAF1B enhances interferon activity in myeloproliferative neoplasms
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