PXD037337 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomics explored the feasibility of curcumin as anticancer copper ionophore |
Description | As an essential micronutrient element in organisms, copper controls a host of fundamental cellular functions. Recently, copper-dependent cell growth and proliferation have been defined as "cuproplasia". Conversely, “cuproptosis” represents copper-dependent cell death, a nonapoptotic manner. So far, a series of copper ionophores have been developed to kill cancer cells. However, the biological response mechanism of copper uptake still lacks systematic analysis. Based on quantitative proteomics, we explored the feasibility of curcumin as anticancer copper ionophore. The copper ionophore curcumin can control the metabolisms of lipids, RNA, NADH and NADPH in colorectal cancer cells, and also up-regulates positive cuproptosis mediators. This work discolored the suppression and acceleration of cuproptosis by GSH and curcumin, respectively. Our results are significative for understanding cuproptosis process and developing novel anticancer reagents based on cuproptosis. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:58:17.924.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Xiang Li |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-10-12 08:33:16 | ID requested | |
1 | 2022-11-17 04:25:03 | announced | |
⏵ 2 | 2023-11-14 08:58:18 | announced | 2023-11-14: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Curcumin,curcumin |
Contact List
Xiang Li |
contact affiliation | College of Chemistry and Chemical Engineering, Hubei University, Wuhan, 430062, Hubei, P. R. China. |
contact email | Lixiang199284@hubu.edu.cn |
lab head | |
Xiang Li |
contact affiliation | Hubei University |
contact email | Lixiang199284@hubu.edu.cn |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD037337
- Label: PRIDE project
- Name: Proteomics explored the feasibility of curcumin as anticancer copper ionophore