PXD037265 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Total Proteomics of SARS-CoV-2 variants |
Description | The ancestral SARS-CoV-2 strain that initiated the Covid-19 pandemic at the end of 2019 has rapidly mutated into multiple variants of concern with variable pathogenicity and increasing immune escape strategies. However, differences in host cellular antiviral responses upon infection with SARS-CoV-2 variants remains elusive. Leveraging whole cell proteomics, we determined host signalling pathways that are differentially modulated upon infection with the clinical isolates of the ancestral SARS-CoV-2 B.1 and the variants of concern Delta and Omicron BA.1. Our findings illustrate alterations in the global host proteome landscape upon infection with SARS-CoV-2 variants and the resulting host immune responses. Additionally, viral proteome kinetics reveal declining levels of viral protein expression during Omicron BA.1 infection when compared to ancestral B.1 and Delta variants, consistent with its reduced replication rates. Moreover, molecular assays reveal deferral activation of specific host antiviral signalling upon Omicron BA.1 and BA.2 infection. Our study provides an overview of host proteome profile of multiple SARS-CoV-2 variants and brings forth a better understanding of the instigation of key immune signalling pathways causative for the differential pathogenicity of SARS-CoV-2 variants. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:47:57.791.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD037265 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Christian Münch |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-10-10 07:56:35 | ID requested | |
1 | 2023-05-10 16:05:39 | announced | |
⏵ 2 | 2023-11-14 08:47:58 | announced | 2023-11-14: Updated project metadata. |
3 | 2023-12-08 16:49:11 | announced | 2023-12-09: Updated project metadata. |
Publication List
Metzler M, Tharyan RG, Klann K, Grikscheit K, Bojkova D, Cinatl J, Tascher G, Ciesek S, M, ü, nch C, SARS-CoV-2 Variants Show Different Host Cell Proteome Profiles With Delayed Immune Response Activation in Omicron-Infected Cells. Mol Cell Proteomics, 22(5):100537(2023) [pubmed] |
Keyword List
submitter keyword: Delta, SARS-CoV-2,Omicron |
Contact List
Christian Münch |
contact affiliation | Faculty of Medicine, Institute of Biochemistry II, Goethe University, 60590 Frankfurt am Main, Germany. Frankfurt Cancer Institute, Goethe University, 60596 Frankfurt am Main, Germany. Cardio-Pulmonary Institute, Goethe University, 60590 Frankfurt am Main, Germany |
contact email | ch.muench@em.uni-frankfurt.de |
lab head | |
Christian Münch |
contact affiliation | Goethe University Frankfurt |
contact email | ch.muench@em.uni-frankfurt.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/05/PXD037265 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD037265
- Label: PRIDE project
- Name: Total Proteomics of SARS-CoV-2 variants