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PXD037198 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAnalysis of the effect of ClpC1 directed antibiotics on ClpC1, ClpC2 and ClpC3 protein levels.
DescriptionEcumicin and Cyclomarin A (CymA) are known antimicrobial compounds that target the NTD of ClpC1. In proteomics analysis of compound treated M. smegmatis, two novel protein, ClpC2 and ClpC3, have been identified as strong interactors of those compounds in addition to ClpC1. In this study we used PRM to monitor the levels of ClpC1, ClpC2 and ClpC3 over time after treatment with CymA or ecumicin or CymA-based BacPROTACs.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterDavid Hoi
SpeciesList scientific name: Mycolicibacterium smegmatis; NCBI TaxID: 1772;
ModificationListCarbamidomethyl; Oxidation; Label:13C(6)15N(4)
InstrumentQ Exactive HF-X; Orbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-10-06 20:50:37ID requested
12023-06-07 14:51:42announced
Publication List
Hoi DM, Junker S, Junk L, Schwechel K, Fischel K, Podlesainski D, Hawkins PME, van Geelen L, Kaschani F, Leodolter J, Morreale FE, Kleine S, Guha S, Rumpel K, Schmiedel VM, Weinstabl H, Meinhart A, Payne RJ, Kaiser M, Hartl M, Boehmelt G, Kazmaier U, Kalscheuer R, Clausen T, Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival. Cell, 186(10):2176-2192.e22(2023) [pubmed]
Keyword List
submitter keyword: BacPROTAC, PROTAC, protein degradation, TPD, antibiotics
Contact List
Markus Hartl
contact affiliationMax Perutz Labs
contact emailmarkus.hartl@univie.ac.at
lab head
David Hoi
contact affiliationMax Perutz Labs, Institute of Molecular Pathology
contact emaildavid.hoi@imp.ac.at
dataset submitter
Full Dataset Link List
Panorama Public dataset URI