PXD037150-1

PXD037150 is an original dataset announced via ProteomeXchange.

Title	Interplay between acetylation and ubiquitination of Isw1 confers multidrug resistance in Cryptococcus neoformans
Description	Lysine acetylation and ubiquitination are one of many protein modifications and play a crucial role in the biological regulation of many organisms, but little is known about the relationship between acetylation and ubiquitination few. Here, the Isw1 protein is an important member of the chromatin remodeling complex, and we performed single-protein modification mass spectrometry detection of the C. neoformans Isw1 protein and site mutations for both detected modifications. The data showed that the two modifications of Cryptococcus neoformans Isw1 protein have a balance of each other. Acetylation can maintain protein stability and maintain protein function, while ubiquitination can reduce protein level and maintain Isw1 protein expression. The expression level of Isw1 protein leads to resistance to antifungal drugs. These results reveal the resistance mechanism of Isw1 protein of Cryptococcus neoformans to antifungal drugs.
HostingRepository	PRIDE
AnnounceDate	2022-12-26
AnnouncementXML	Submission_2022-12-26_06:19:39.803.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	mengyang
SpeciesList	scientific name: Candida albicans (Yeast); NCBI TaxID: 5476;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-10-03 11:19:11	ID requested
⏵ 1	2022-12-26 06:19:40	announced

Dataset with its publication pending

submitter keyword: acetylation

ubiquitination

multidrug resistance

YangMeng
contact affiliation	College of Life and Health Sciences, Northeastern University, Shenyang, China.
contact email	MMMyang0130@163.com
lab head
mengyang
contact affiliation	13940381361
contact email	MMMyang0130@163.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD037150
     1. Label: PRIDE project
     2. Name: Interplay between acetylation and ubiquitination of Isw1 confers multidrug resistance in Cryptococcus neoformans