PXD037116-1

PXD037116 is an original dataset announced via ProteomeXchange.

Title	DIURNAL REGULATION OF HEPATIC PROTEIN PROCESSING AND SECRETION
Description	The liver is a major regulator of homeostasis and physiology and acts as an endocrine organ secreting the majority of blood proteins. Dysregulations of hepatic protein secretion are implicated with pathophysiology. Thus, the understanding of the underlying mechanisms of how protein secretion is regulated is crucial. We have previously shown that protein secretion in mouse liver is diurnal. To further elucidate rhythmic protein secretion, we collected mouse liver samples over the course of the day and performed a proteomic study of microsomal fractions containing the proteins of the secretory pathway. An enrichment analysis of rhythmic proteins highlighted proteins linked to endoplasmic reticulum (ER) and Golgi apparatus (GA) function, mainly including proteins involved in protein folding and glycosylation.
HostingRepository	PRIDE
AnnounceDate	2025-12-17
AnnouncementXML	Submission_2025-12-17_11:50:48.036.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Manfredo Quadroni
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	6x(13)C labeled residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-09-30 04:10:11	ID requested
⏵ 1	2025-12-17 11:50:48	announced

Dataset with its publication pending

submitter keyword: circadian

liver

secretion

endopasmic reticulum

golgi apparatus

Frederic Gachon
contact affiliation	Institute for Molecular Biosciences University of Queensland Brisbane Qld 4072 Australia
contact email	f.gachon@imb.uq.edu.au
lab head
Manfredo Quadroni
contact affiliation	University of Lausanne
contact email	manfredo.quadroni@unil.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD037116

PRIDE project URI

• PRIDE
  1. PXD037116
     1. Label: PRIDE project
     2. Name: DIURNAL REGULATION OF HEPATIC PROTEIN PROCESSING AND SECRETION