PXD037098-1

PXD037098 is an original dataset announced via ProteomeXchange.

Title	Multi-omics Analyses Reveal Sex Differences in Mouse Renal Proximal Tubules
Description	Sex-dependent differences in kidney function have been recognized. However, the molecular mechanisms underlying these differences remain largely unexplored. Advances in genomics and proteomic technologies now allow for an extensive characterization of sex differences. In this study, the authors apply multi-omics approaches integrating RNA-seq, ATAC-seq, and proteomics to investigate gene expression, chromatin accessibility, and protein expression between male and female mouse proximal tubules. This study identifies a large number of sex-biased genes and proteins associated with various kidney functions, including metabolism and transport processes. The authors demonstrate that sex differences may also arise from differences in interaction between transcription factors and accessible chromatin regions. A comprehensive web resource is provided to the research community to advance understanding of sex differences.
HostingRepository	PRIDE
AnnounceDate	2023-05-05
AnnouncementXML	Submission_2023-05-05_09:51:03.719.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	CHIN-RANGYANG
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2022-09-30 03:57:44	ID requested
⏵ 1	2023-05-05 09:51:04	announced
2	2023-11-14 08:58:06	announced	2023-11-14: Updated project metadata.

submitter keyword: Kidney, Multi-omics,Sex Difference

Mark A.Knepper
contact affiliation	Epithelial Systems Biology Laboratory Systems Biology Center Division of Intramural Research National Heart, Lung and Blood Institute Building 10, Room 6N307 Bethesda, Maryland 20895-1603
contact email	knepperm@nhlbi.nih.gov
lab head
CHIN-RANGYANG
contact affiliation	National Institutes of Health, USA
contact email	chin-rang.yang@nih.gov
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD037098
     1. Label: PRIDE project
     2. Name: Multi-omics Analyses Reveal Sex Differences in Mouse Renal Proximal Tubules