PXD037093 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Isolation and Characterization of ZK002, A Novel Dual Function Snake Venom Peptide from Deinagkistrodon acutus with Anti-angiogenic and Anti-inflammatory Properties |
Description | Pathological angiogenesis, the abnormal or excessive generation of blood vessels, plays an important role in many diseases including cancer, diabetic retinopathy, psoriasis, and arthritis. Additionally, increasing evidence supports the close linkage between angiogenesis and inflammation. Snake venoms are a rich natural source of biologically active molecules and carry rich potential for the discovery anti-angiogenic and anti-inflammatory modulators. Here, we isolated and purified a novel protein, ZK002, from the venom of the snake Deinagkistrodon acutus, and investigated its anti-angiogenic and anti-inflammatory activities and mechanisms. |
HostingRepository | PRIDE |
AnnounceDate | 2023-10-24 |
AnnouncementXML | Submission_2023-10-24_10:50:33.492.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD037093 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | William Chi-ShingTai |
SpeciesList | scientific name: Deinagkistrodon acutus; NCBI TaxID: 36307; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-09-30 03:47:30 | ID requested | |
⏵ 1 | 2023-10-24 10:50:34 | announced | |
2 | 2023-11-14 09:06:43 | announced | 2023-11-14: Updated project metadata. |
Publication List
10.6019/PXD037093; |
Chan BD, Wong WY, Lee MM, Yue PY, Dai X, Tsim KW, Hsiao WW, Li M, Li XY, Tai WC, with anti-angiogenic and anti-inflammatory properties. Front Pharmacol, 14():1227962(2023) [pubmed] |
Keyword List
submitter keyword: ZK002 |
snake venom |
anti-angiogenesis |
anti-inflammation |
Contact List
William Chi-ShingTai |
contact affiliation | Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hung Hom, Hong Kong S.A.R., China |
contact email | william-cs.tai@polyu.edu.hk |
lab head | |
William Chi-ShingTai |
contact affiliation | The Hong Kong Polytechnic University |
contact email | william-cs.tai@polyu.edu.hk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD037093
- Label: PRIDE project
- Name: Isolation and Characterization of ZK002, A Novel Dual Function Snake Venom Peptide from Deinagkistrodon acutus with Anti-angiogenic and Anti-inflammatory Properties